The Buffalo Bills will host the San Francisco 49ers at Highmark Stadium in Orchard Park, New York, on Sunday, December 1, at ...

The results were ugly for the San Francisco 49ers last week against the Green Bay Packers without starting quarterback Brock ...

In honor of World Aids Day, San Franciscans came together at the National AIDS Memorial Grove in San Francisco on Saturday ...

Analyzing Sunday’s San Francisco 49ers at Buffalo Bills odds and lines, with expert NFL picks and predictions.

The San Francisco 49ers promoted CB Nick McCloud to the active roster from the team's practice squad and activated LB Jalen ...

A USC student was one of three people killed in a Tesla Cybertruck crash early Wednesday in Piedmont, the university ...

Columnist David Marcus warns Democrat mayors that resisting incoming President Trump's plans to deport illegal immigrants ...

An energy efficient government building in California – once ridiculed by President-elect Trump – will be formally dedicated ...

A 3,650-square-foot corner “mega loft” in San Francisco’s famous SoMa district is the result of a renovation combining three units, and the home and work space is now on the market for $3.2 million.

The arrow is pointing upward for Brock Purdy. On Friday, the 49ers delivered encouraging news on Purdy's status vs Buffalo in ...

While the holidays are about gathering together with your loved ones at the dinner table, that is not always possible.

For decades, the Macy's Store at San Francisco's Union Square has been a focal point of ... Reports of local developers being ...