Christian McCaffrey rarely has been taken off the field since returning from an eight-game absence due to bilateral Achilles ...

They have a tough game in Buffalo on Sunday night. A loss would further complicate their path to the postseason.So how is ...

The San Francisco 49ers are preparing for their Week 13 contest against the Buffalo Bills on Sunday at Highmark Stadium in ...

"We're just going to keep chopping wood," said running back Christian McCaffrey, as more 49ers stars grapple with ...

Through the first four weeks of the season, Fred Warner was the front-runner to win the Defensive Player of the Year Award.

Deebo Samuel probably is the most disappointing player on the most disappointing team in the NFL through 12 weeks. Here's ...

The early portion of Wednesday's practice produced no encouraging signs for 49ers quarterback Brock Purdy. Brandon Allen, ...

This is a crucial week for the San Francisco 49ers. After Thanksgiving, they travel to face the Buffalo Bills on Sunday Night ...

Bad news for the 49ers. Brock Purdy still isn't ready to resume throwing. Technically, he threw one pass on Wednesday -- a ...

San Francisco 49ers defensive end Nick Bosa missed Wednesday's practice as the team began preparations for Sunday's game ...

The San Francisco 49ers have officially opened linebacker Dre Greenlaw's 21-day practice window, giving the team until ...

After the San Francisco 49ers' crushing 38-10 defeat to the Green Bay Packers on Sunday, Eric Branch of the San Francisco ...