The San Francisco 49ers (5-6) try to salvage their season against the Buffalo Bills (9-2) on Sunday Night Football. Kickoff from Highmark Stadium is set for 8:20 p.m. ET (NBC). Let's analyze BetM

After that, there is no significant NFL talent on the 49ers roster, while the edges are equally deficient in both depth and run-stopping abilities. For that reason, the Bills may pursue interior runs early and often while San Francisco struggles to find ...

Coming into the 2024 NFL season, it wouldn't have been out of the ordinary to find a Super Bowl prediction featuring the Buffalo Bills or San Francisco 49ers, or both. Josh Allen's AFC squad entered looking for its sixth straight playoff appearance.

SportsLine's model has simulated San Francisco vs. Buffalo on Sunday Night Football 10,000 times and revealed its SNF picks and NFL predictions

They don't get a divisional opponent in Week 13, but a struggling San Francisco 49ers team still possesses plenty of firepower for Buffalo to be concerned with as it starts December. Here are five keys to victory for the Bills as they welcome the 49ers into Orchard Park,

Dive into the San Francisco 49ers vs. Buffalo Bills showdown with a look at odds, predictions, and the best betting options.

Under head coach Kyle Shanahan, the San Francisco 49ers have spent years falling just inches short of the franchise’s sixth Lombardi Trophy. The Niners have mad

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The San Francisco 49ers were among the Super Bowl favorites heading into the season, but they find themselves below the .500 mark heading into their matchup against Buffalo during the Week 13 NFL schedule.

Yet on Sunday night in frigid Orchard Park, the 49ers, mired at 5-6 and a game out of first place in the NFC West, find their season hanging in the balance with a showdown against the 9-2 Bills.

The Buffalo Bills have activated Matt Milano from injured reserve, putting the starting linebacker in position to play Sunday night against the San Francisco 49ers.